Analysis of gut microbiota alteration and application as an auxiliary prognostic marker for sepsis in children: a pilot study.

ABSTRACT:

Background

Emerging evidence suggests that gut microbiota dysbiosis plays a role in sepsis. Recent advances in sequencing technology enable the characterization of the gut microbiota and can provide clues for the pathogenesis of sepsis, which may help develop biomarkers for diagnosis or prognosis prediction in children with sepsis.

Methods

The gut microbiota from 25 children with sepsis and 15 age- and sex-matched healthy controls were extracted and sequenced by high-throughput Illumina Hiseq, targeting the 16S rDNA genes. The differences of gut microbiota between the two groups were analyzed to assess if the gut microbiota can be used as an auxiliary prognostic marker for sepsis.

Results

The diversity of gut microbiota in children with sepsis was significantly lower

SUBMITTER: Du B 

PROVIDER: S-EPMC8261590 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature