Effect of Cytisine vs Varenicline on Smoking Cessation: A Randomized Clinical Trial.

ABSTRACT:

Importance

Cytisine is more effective than placebo and nicotine replacement therapy for smoking cessation. However, cytisine has not been tested against the most effective smoking cessation medication, varenicline, which is associated with adverse events known to lead to discontinuation of therapy.

Objective

To examine whether standard cytisine treatment (25 days) was at least as effective as standard varenicline treatment (84 days) for smoking cessation.

Design, setting, and participants

This noninferiority, open-label randomized clinical trial with allocation concealment and blinded outcome assessment was undertaken in Australia from November 2017 through May 2019; follow-up was completed in January 2020. A total of 1452 Australian adult daily smokers willing to mak

SUBMITTER: Courtney RJ 

PROVIDER: S-EPMC8261608 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature