Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel.

ABSTRACT:

Background

BNT162b2 was shown to be 92% effective in preventing COVID-19. Prioritizing vaccine rollout, and achievement of herd immunity depend on SARS-CoV-2 transmission reduction. The vaccine's effect on infectivity is thus a critical priority.

Methods

Among all 9650 HCW of a large tertiary medical center in Israel, we calculated the prevalence of positive SARS-CoV-2 qRT-PCR cases with asymptomatic presentation, tested following known or presumed exposure and the infectious subset (N-gene-Ct-value<30) of these. Additionally, infection incidence rates were calculated for symptomatic cases and infectious (Ct<30) cases. Vaccine effectiveness within three months of vaccine rollout was measured as one minus the relative risk or rate ratio, respectively. To further assess infect

SUBMITTER: Regev-Yochay G 

PROVIDER: S-EPMC8261633 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature