Ontology highlight
ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC8261666 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Zhao Wei W Qiao Lingxia L Yan Shiyu S Nie Qing Q Zhang Lei L
iScience 20210617 7
Bivalent chromatin is characterized by occupation of both activating and repressive histone modifications. Here, we develop a mathematical model that involves antagonistic histone modifications H3K4me3 and H3K27me3 to capture the key features of bivalent chromatin. Three necessary conditions for the emergence of bivalent chromatin are identified, including advantageous methylating activity over demethylating activity, frequent noise conversions of modifications, and sufficient nonlinearity. The ...[more]