Differences in the effects of BMI on bone microstructure between loaded and unloaded bones assessed by HR-pQCT in Japanese postmenopausal women.

ABSTRACT:

Objectives

The relationship between weight-related load and bone mineral density (BMD)/bone microstructure under normal load conditions using high-resolution peripheral quantitative computed tomography (HR-pQCT) remains unconfirmed. The study aims to investigate the differences in effect of body mass index (BMI) on BMD/bone microstructure of loaded and unloaded bones, respectively, in Japanese postmenopausal women.

Methods

Fifty-seven postmenopausal women underwent HR-pQCT on the tibia and radius. Correlation analysis, principal component (PC) analysis, and hierarchical multiple regression were performed to examine the relationship between BMI and HR-pQCT parameters.

Results

Several microstructural parameters of the tibia and radius correlated with BMI through a simpl

SUBMITTER: Fujii N 

PROVIDER: S-EPMC8261728 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature