The role of RORγt at maternal-fetal interface during murine pregnancy.

ABSTRACT:

Problem

Innate lymphoid cells (ILCs, including NK cells) and their subsets are the most frequent lymphocytes at the maternal-fetal interface (decidua). Recent recognition of extensive ILC subset diversity at mucosal sites and the possible role they might play at different stages of pregnancy poses questions about their composition and lineage stability. Namely, RORγt-dependent ILC3s have been recognized as a key cellular mediator of tissue organization in the gut and secondary lymphoid organs, prompting examination of their distribution and role in decidua during pregnancy.

Method of study

We employed highly polychromatic flow cytometry with conventional and machine learning-aided analysis to map ILC subsets and dissected the role of canonical transcription factor RORγt usin

SUBMITTER: Li Y 

PROVIDER: S-EPMC8261794 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature