Chronic obstructive pulmonary disease does not impair responses to resistance training.

ABSTRACT:

Background

Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach.

Methods

Subjects with COPD (n = 20, GOLD II-III, FEV_1predicted 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV_1predict

SUBMITTER: Molmen KS 

PROVIDER: S-EPMC8261934 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature