Genetic evidence for a causative effect of airflow obstruction on left ventricular filling: a Mendelian randomisation study.

ABSTRACT:

Background

Observational studies on the general population have suggested that airflow obstruction associates with left ventricular (LV) filling. To limit the influence of environmental risk factors/exposures, we used a Mendelian randomisation (MR) approach based on common genetic variations and tested whether a causative relation between airflow obstruction and LV filling can be detected.

Methods

We used summary statistics from large genome-wide association studies (GWAS) on the ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) measured by spirometry and the LV end-diastolic volume (LVEDV) as assessed by cardiac magnetic resonance imaging. The primary MR was based on an inverse variance weighted regression. Various complementary MR methods and sub

SUBMITTER: Harbaum L 

PROVIDER: S-EPMC8261939 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature