Human-derived acellular dermal matrix may be an alternative to autologous grafts in tympanic membrane reconstruction: systematic review and meta-analysis.

ABSTRACT:

Background

Human-derived acellular dermal matrix (ADM) has been widely used as an effective alternative to autologous grafts in tympanoplasty. However, evidence of ADM as an alternative to autologous grafts in the repair of tympanic membrane (TM) perforation still lacks adequate empirical evidence.

Objectives

To determine the clinical safety and efficacy of human-derived ADM as TM graft material for tympanoplasty.

Data sources

The PubMed, EMBASE, Cochrane Library, EBSCO, Ovid, Scopus, and Web of Science databases and reference lists of the retrieved articles were searched, with no language restriction.

Selection criteria

All randomized controlled trials and retrospective cohort studies that compared the use of human-derived ADM and autologous grafts in tympanop

SUBMITTER: Xu S 

PROVIDER: S-EPMC8261972 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature