The effects of exercise training versus intensive insulin treatment on skeletal muscle fibre content in type 1 diabetes mellitus rodents.

ABSTRACT:

Background

Intensive-insulin treatment (IIT) strategy for patients with type 1 diabetes mellitus (T1DM) has been associated with sedentary behaviour and the development of insulin resistance. Exercising patients with T1DM often utilize a conventional insulin treatment (CIT) strategy leading to increased insulin sensitivity through improved intramyocellular lipid (IMCL) content. It is unclear how these exercise-related metabolic adaptations in response to exercise training relate to individual fibre-type transitions, and whether these alterations are evident between different insulin strategies (CIT vs. IIT).

Purpose

This study examined glycogen and fat content in skeletal muscle fibres of diabetic rats following exercise-training.

Methods

Male Sprague-Dawley rats were

SUBMITTER: McBey DP 

PROVIDER: S-EPMC8262066 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature