Identification of Prognostic Related Genes of Tumor Microenvironment Derived From Esophageal Cancer Patients.

ABSTRACT: Background and Objective: Esophageal cancer (ESCA) is a commonly occurring cancer worldwide with poor survival and limited therapeutic options. Due to the lack of biomarkers that facilitate early detection, its treatment remains a great challenge. This study aims at identifying the tumor microenvironment (TME)-related genes, which might affect prognosis and accelerate clinical treatment for ESCA patients. Methods: We integrated the expression profiles from ESCA patients in The Cancer Genome Atlas. Then, we determined the stromal and immune scores of each sample using the R package. The Gene Expression Omnibus database was used to validate the expression profile of the key genes. Results: Tumor mutational burden showed a significant difference between the groups of ESCA

SUBMITTER: Yuan W 

PROVIDER: S-EPMC8262216 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature