Development of a Novel Prognostic Signature Based on Antigen Processing and Presentation in Patients with Breast Cancer.

ABSTRACT: Background: Complex antigen processing and presentation processes are involved in the development and progression of breast cancer (BC). A single biomarker is unlikely to adequately reflect the complex interplay between immune cells and cancer; however, there have been few attempts to find a robust antigen processing and presentation-related signature to predict the survival outcome of BC patients with respect to tumor immunology. Therefore, we aimed to develop an accurate gene signature based on immune-related genes for prognosis prediction of BC. Methods: Information on BC patients was obtained from The Cancer Genome Atlas. Gene set enrichment analysis was used to confirm the gene set related to antigen processing and presentation that contributed to BC. Cox proportional re

SUBMITTER: Qi A 

PROVIDER: S-EPMC8262234 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature