Distinctive waves of innate immune response in the retina in experimental autoimmune encephalomyelitis.

ABSTRACT: Neurodegeneration mediates neurological disability in inflammatory demyelinating diseases of the CNS. The role of innate immune cells in mediating this damage has remained controversial with evidence for destructive and protective effects. This has complicated efforts to develop treatment. The time sequence and dynamic evolution of the opposing functions are especially unclear. Given limits of in vivo monitoring in human diseases such as multiple sclerosis (MS), animal models are warranted to investigate the association and timing of innate immune activation with neurodegeneration. Using noninvasive in vivo retinal imaging of experimental autoimmune encephalitis (EAE) in CX3CR1GFP/+-knock-in mice followed by transcriptional profiling, we are able to show 2 distinct waves separated by a mar

SUBMITTER: Cruz-Herranz A 

PROVIDER: S-EPMC8262300 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature