Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.

ABSTRACT: Extensive activation of glial cells during a latent period has been well documented in various animal models of epilepsy. However, it remains unclear whether activated glial cells contribute to epileptogenesis, i.e., the chronically persistent process leading to epilepsy. Particularly, it is not clear whether interglial communication between different types of glial cells contributes to epileptogenesis, because past literature has mainly focused on one type of glial cell. Here, we show that temporally distinct activation profiles of microglia and astrocytes collaboratively contributed to epileptogenesis in a drug-induced status epilepticus model. We found that reactive microglia appeared first, followed by reactive astrocytes and increased susceptibility to seizures. Reactive astrocytes ex

SUBMITTER: Sano F 

PROVIDER: S-EPMC8262323 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature