Washed Microbiota Transplantation Accelerates the Recovery of Abnormal Changes by Light-Induced Stress in Tree Shrews.

ABSTRACT: The gut and brain interact constantly in a complex fashion. Its intricacy and intrigue is progressively being revealed in the study of the "gut-brain axis". Among many factors, abnormal light exposure is a potential powerful stressor, which is becoming ever more pervasive in our modern society. However, little is known about how stress, induced by staying up late by light, affects the gut-brain axis. We addressed this question by extending the normal circadian light for four hours at night in fifteen male tree shrews to simulate the pattern of staying up late in humans. The behavior, biochemical tests, microbiota dynamics, and brain structure of tree shrews were evaluated. The simple prolongation of light in the environment resulted in substantial changes of body weight loss, behavioral di

SUBMITTER: Wang J 

PROVIDER: S-EPMC8262326 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature