Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis.

ABSTRACT:

Objective

To investigate the efficacy, acceptability, and safety of muscle relaxants for low back pain.

Design

Systematic review and meta-analysis of randomised controlled trials.

Data sources

Medline, Embase, CINAHL, CENTRAL, ClinicalTrials.gov, clinicialtrialsregister.eu, and WHO ICTRP from inception to 23 February 2021.

Eligibility criteria for study selection

Randomised controlled trials of muscle relaxants compared with placebo, usual care, waiting list, or no treatment in adults (≥18 years) reporting non-specific low back pain.

Data extraction and synthesis

Two reviewers independently identified studies, extracted data, and assessed the risk of bias and certainty of the evidence using the Cochrane risk-of-bias tool and Grading of Recommendations, A

SUBMITTER: Cashin AG 

PROVIDER: S-EPMC8262447 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature