Effects of mechanical loading on cortical defect repair using a novel mechanobiological model of bone healing.

ABSTRACT: Mechanical loading is an important aspect of post-surgical fracture care. The timing of load application relative to the injury event may differentially regulate repair depending on the stage of healing. Here, we used a novel mechanobiological model of cortical defect repair that offers several advantages including its technical simplicity and spatially confined repair program, making effects of both physical and biological interventions more easily assessed. Using this model, we showed that daily loading (5N peak load, 2Hz, 60 cycles, 4 consecutive days) during hematoma consolidation and inflammation disrupted the injury site and activated cartilage formation on the periosteal surface adjacent to the defect. We also showed that daily loading during the matrix deposition phase enhanced bot

SUBMITTER: Liu C 

PROVIDER: S-EPMC8262576 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature