Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.

ABSTRACT: Selective targeting of aneuploid cells is an attractive strategy for cancer treatment¹. However, it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer cells. Here we mapped the aneuploidy landscapes of about 1,000 human cancer cell lines, and analysed genetic and chemical perturbation screens^2-9 to identify cellular vulnerabilities associated with aneuploidy. We found that aneuploid cancer cells show increased sensitivity to genetic perturbation of core components of the spindle assembly checkpoint (SAC), which ensures the proper segregation of chromosomes during mitosis¹⁰. Unexpectedly, we also found that aneuploid cancer cells were less sensitive than diploid cells to short-term exposure to multiple SAC inhibitors. I

SUBMITTER: Cohen-Sharir Y 

PROVIDER: S-EPMC8262644 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature