PERCEPTRON: an open-source GPU-accelerated proteoform identification pipeline for top-down proteomics.

ABSTRACT: PERCEPTRON is a next-generation freely available web-based proteoform identification and characterization platform for top-down proteomics (TDP). PERCEPTRON search pipeline brings together algorithms for (i) intact protein mass tuning, (ii) de novo sequence tags-based filtering, (iii) characterization of terminal as well as post-translational modifications, (iv) identification of truncated proteoforms, (v) in silico spectral comparison, and (vi) weight-based candidate protein scoring. High-throughput performance is achieved through the execution of optimized code via multiple threads in parallel, on graphics processing units (GPUs) using NVidia Compute Unified Device Architecture (CUDA) framework. An intuitive graphical web interface allows for setting up of search parameters as well as fo

SUBMITTER: Khalid MF 

PROVIDER: S-EPMC8262694 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature