Mergeomics 2.0: a web server for multi-omics data integration to elucidate disease networks and predict therapeutics.

ABSTRACT: The Mergeomics web server is a flexible online tool for multi-omics data integration to derive biological pathways, networks, and key drivers important to disease pathogenesis and is based on the open source Mergeomics R package. The web server takes summary statistics of multi-omics disease association studies (GWAS, EWAS, TWAS, PWAS, etc.) as input and features four functions: Marker Dependency Filtering (MDF) to correct for known dependency between omics markers, Marker Set Enrichment Analysis (MSEA) to detect disease relevant biological processes, Meta-MSEA to examine the consistency of biological processes informed by various omics datasets, and Key Driver Analysis (KDA) to identify essential regulators of disease-associated pathways and networks. The web server has been extensively u

SUBMITTER: Ding J 

PROVIDER: S-EPMC8262738 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature