Proteo3Dnet: a web server for the integration of structural information with interactomics data.

ABSTRACT: Proteo3Dnet is a web server dedicated to the analysis of mass spectrometry interactomics experiments. Given a flat list of proteins, its aim is to organize it in terms of structural interactions to provide a clearer overview of the data. This is achieved using three means: (i) the search for interologs with resolved structure available in the protein data bank, including cross-species remote homology search, (ii) the search for possibly weaker interactions mediated through Short Linear Motifs as predicted by ELM-a unique feature of Proteo3Dnet, (iii) the search for protein-protein interactions physically validated in the BioGRID database. The server then compiles this information and returns a graph of the identified interactions and details about the different searches. The graph can be i

SUBMITTER: Postic G 

PROVIDER: S-EPMC8262742 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature