The gutSMASH web server: automated identification of primary metabolic gene clusters from the gut microbiota.

ABSTRACT: Anaerobic bacteria from the human microbiome produce a wide array of molecules at high concentrations that can directly or indirectly affect the host. The production of these molecules, mostly derived from their primary metabolism, is frequently encoded in metabolic gene clusters (MGCs). However, despite the importance of microbiome-derived primary metabolites, no tool existed to predict the gene clusters responsible for their production. For this reason, we recently introduced gutSMASH. gutSMASH can predict 41 different known pathways, including MGCs involved in bioenergetics, but also putative ones that are candidates for novel pathway discovery. To make the tool more user-friendly and accessible, we here present the gutSMASH web server, hosted at https://gutsmash.bioinformatics.nl/. The

SUBMITTER: Pascal Andreu V 

PROVIDER: S-EPMC8262752 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature