Immunological Responses to Transgene-Modified Neural Stem Cells After Transplantation.

ABSTRACT: Neural stem cell (NSC) therapy is a promising therapeutic strategy for stroke. Researchers have frequently carried out genetic modification or gene editing of stem cells to improve survival or therapeutic function. However, NSC transplantation carries the risk of immune rejection, and genetic modification or gene-editing might further increase this risk. For instance, recent studies have reported on manipulating the stem cell genome and transplantation via the insertion of an exogenous gene derived from magnetotactic bacteria. However, whether transgene-modified stem cells are capable of inducing immunological reactions has not been explored. Although NSCs rarely express the major histocompatibility complex (MHC), they can still cause some immunological issues. To investigate whethe

SUBMITTER: Wei N 

PROVIDER: S-EPMC8262771 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature