Immune Gene Expression Covaries with Gut Microbiome Composition in Stickleback.

ABSTRACT: Commensal microbial communities have immense effects on their vertebrate hosts, contributing to a number of physiological functions, as well as host fitness. In particular, host immunity is strongly linked to microbiota composition through poorly understood bi-directional links. Gene expression may be a potential mediator of these links between microbial communities and host function. However, few studies have investigated connections between microbiota composition and expression of host immune genes in complex systems. Here, we leverage a large study of laboratory-raised fish from the species Gasterosteus aculeatus (three-spined stickleback) to document correlations between gene expression and microbiome composition. First, we examined correlations between microbiome alpha diversit

SUBMITTER: Fuess LE 

PROVIDER: S-EPMC8262870 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature