Enhanced Carbapenem Resistance through Multimerization of Plasmids Carrying Carbapenemase Genes.

ABSTRACT: The worldwide dissemination of carbapenem-resistant Enterobacteriaceae (CRE) poses a critical human health issue by limiting the range of antibiotics that are usable in the treatment of common bacterial infections. Along with CRE, carbapenem heteroresistance has disseminated worldwide, which is described as different levels of carbapenem resistance within a seemingly isogenic bacterial population. Unstable carbapenem resistance will likely lead to unexpected treatment failure due to the enhanced resistance after initiation of treatment, contradicting antimicrobial susceptibility test results. Porin mutation and tandem amplification of the carbapenemase gene have been reported as mechanisms underlying enhanced carbapenem resistance. In this study, we identified multimerization of pla

SUBMITTER: Abe R 

PROVIDER: S-EPMC8262910 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature