Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila.

ABSTRACT: The mucophilic anaerobic bacterium Akkermansia muciniphila is a prominent member of the gastrointestinal (GI) microbiota and the only known species of the Verrucomicrobia phylum in the mammalian gut. A high prevalence of A. muciniphila in adult humans is associated with leanness and a lower risk for the development of obesity and diabetes. Four distinct A. muciniphila phylogenetic groups have been described, but little is known about their relative abundance in humans or how they impact human metabolic health. In this study, we isolated and characterized 71 new A. muciniphila strains from a cohort of children and adolescents undergoing treatment for obesity. Based on genomic and phenotypic analysis of these strains, we found several phylogroup-specific ph

SUBMITTER: Becken B 

PROVIDER: S-EPMC8262928 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature