Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model.

ABSTRACT: Antibiotic-resistant Staphylococcus aureus strains constitute a major public health concern worldwide and are responsible for both health care- and community-associated infections. Here, we establish a robust and easy-to-implement model of oral S. aureus infection using Drosophila melanogaster larvae that allowed us to follow the fate of S. aureus at the whole-organism level as well as the host immune responses. Our study demonstrates that S. aureus infection triggers H₂O₂ production by the host via the Duox enzyme, thereby promoting antimicrobial peptide production through activation of the Toll pathway. Staphylococcal catalase mediates H₂O₂ neutralization, which not only promotes S. aureus survival but also minimizes the host antimicrobial resp

SUBMITTER: Ramond E 

PROVIDER: S-EPMC8262968 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature