Divergent Cytochrome c Maturation System in Kinetoplastid Protists.

ABSTRACT: In eukaryotes, heme attachment through two thioether bonds to mitochondrial cytochromes c and c₁ is catalyzed by either multisubunit cytochrome c maturation system I or holocytochrome c synthetase (HCCS). The former was inherited from the alphaproteobacterial progenitor of mitochondria; the latter is a eukaryotic innovation for which prokaryotic ancestry is not evident. HCCS provides one of a few exemplars of de novo protein innovation in eukaryotes, but structure-function insight of HCCS is limited. Uniquely, euglenozoan protists, which include medically relevant kinetoplastids Trypanosoma and Leishmania parasites, attach heme to mitochondrial c-type cytochromes by a single thioether linkage. Yet the mechanism is unknown,

SUBMITTER: Belbelazi A 

PROVIDER: S-EPMC8262978 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature