HIV-1 Vpr Induces Widespread Transcriptomic Changes in CD4⁺ T Cells Early Postinfection.

ABSTRACT: The interactions between a virus and its host are complex but can be broadly categorized as either viral manipulation of cellular functions or cellular responses to infection. These processes begin at the earliest point of contact between virus and cell and frequently result in changes to cellular gene expression, making genome-wide transcriptomics a useful tool to study them. Several previous studies have used transcriptomics to evaluate the cellular responses to human immunodeficiency virus type 1 (HIV-1) infection; however, none have examined events in primary CD4⁺ T cells during the first 24 h of infection. Here, we analyzed CD4⁺ T cells at 4.5, 8, 12, 24, and 48 h following infection. We describe global changes to host gene expression commencing at 4.5 h postinfe

SUBMITTER: Bauby H 

PROVIDER: S-EPMC8263007 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature