DegP Initiates Regulated Processing of Filamentous Hemagglutinin in Bordetella bronchiseptica.

ABSTRACT: Filamentous hemagglutinin (FhaB) is a critical virulence factor for both Bordetella pertussis, the causal agent of whooping cough, and the closely related species Bordetella bronchiseptica. FhaB is an adhesin, suppresses inflammatory cytokine production, and protects against phagocytic cell clearance during infection. Regulated degradation of the FhaB C-terminal prodomain is required to establish a persistent infection in mice. Two proteases, CtpA in the periplasm and SphB1 on the bacterial surface, are known to mediate FhaB processing, and we recently determined that CtpA functions before, and controls the FhaB cleavage site of, SphB1. However, the data indicate that another periplasmic protease must initiate degradation of the prodomain by removing a portion of the FhaB C terminus that i

SUBMITTER: Johnson RM 

PROVIDER: S-EPMC8263021 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature