Factors Associated With Rebound Hyperthermia After Targeted Temperature Management in Out-of-Hospital Cardiac Arrest Patients: An Explorative Substudy of the Time-Differentiated Therapeutic Hypothermia in Out-of-Hospital Cardiac Arrest Survivors Trial.

ABSTRACT: To investigate rebound hyperthermia following targeted temperature management after cardiac arrest and its impact on functional outcome.

Design

Post hoc analysis.

Setting

Ten European ICUs.

Patients

Patients included in the time-differentiated therapeutic hypothermia in out-of-hospital cardiac arrest survivors trial treated with targeted temperature management at 33°C for 48 or 24 hours. Favorable functional outcome was defined as a Cerebral Performance Category of 1 or 2 at 6 months.

Interventions

None.

Measurements and main results

Of 338 included patients, 103 (30%) experienced rebound hyperthermia defined as a maximum temperature after targeted temperature management and rewarming exceeding 38.5°C. Using multivariate logistic regression analysis, incr

SUBMITTER: Holm A 

PROVIDER: S-EPMC8263323 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature