Prospective comparison of ¹⁸F-PSMA-1007 PET/CT, whole-body MRI and CT in primary nodal staging of unfavourable intermediate- and high-risk prostate cancer.

ABSTRACT:

Purpose

To prospectively compare ¹⁸F-prostate-specific membrane antigen (PSMA)-1007 positron emission tomography (PET)/CT, whole-body magnetic resonance imaging (WBMRI) including diffusion-weighted imaging (DWI) and standard computed tomography (CT), in primary nodal staging of prostate cancer (PCa).

Methods

Men with newly diagnosed unfavourable intermediate- or high-risk PCa prospectively underwent ¹⁸F-PSMA-1007 PET/CT, WBMRI with DWI and contrast-enhanced CT within a median of 8 days. Six readers (two for each modality) independently reported pelvic lymph nodes as malignant, equivocal or benign while blinded to the other imaging modalities. Sensitivity, specificity and accuracy were reported according to optimistic (equivocal lesions interpreted as be

SUBMITTER: Malaspina S 

PROVIDER: S-EPMC8263440 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature