Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.

ABSTRACT:

Purpose

A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions.

Methods

The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions, to assess approaches for real-world application of genomic medicine in diverse clinical settings, and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation.

Results

Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk AP

SUBMITTER: Ginsburg GS 

PROVIDER: S-EPMC8263480 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature