A first-in-human study of ¹¹C-MTP38, a novel PET ligand for phosphodiesterase 7.

ABSTRACT:

Purpose

Phosphodiesterase 7 (PDE7) is an enzyme that selectively hydrolyses cyclic adenosine monophosphate, and its dysfunction is implicated in neuropsychiatric diseases. However, in vivo visualization of PDE7 in human brains has hitherto not been possible. Using the novel PET ligand ¹¹C-MTP38, which we recently developed, we aimed to image and quantify PDE7 in living human brains.

Methods

Seven healthy males underwent a 90-min PET scan after injection of ¹¹C-MTP38. We performed arterial blood sampling and metabolite analysis of plasma in six subjects to obtain a metabolite-corrected input function. Regional total distribution volumes (V_Ts) were estimated using compartment models, and Logan plot and Ichise multilinear analysis (MA1). We furt

SUBMITTER: Kubota M 

PROVIDER: S-EPMC8263543 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature