Assessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach.

ABSTRACT: Bipolar disorder (BP) suicide death rates are 10-30 times greater than the general population, likely arising from environmental and genetic risk factors. Though suicidal behavior in BP has been investigated, studies have not addressed combined clinical and genetic factors specific to suicide death. To address this gap, a large, harmonized BP cohort was assessed to identify clinical risk factors for suicide death and attempt which then directed testing of underlying polygenic risks. 5901 individuals of European ancestry were assessed: 353 individuals with BP and 2498 without BP who died from suicide (BPS and NBPS, respectively) from a population-derived sample along with a volunteer-derived sample of 799 individuals with BP and a history of suicide attempt (BPSA), 824 individuals with BP a

SUBMITTER: Monson ET 

PROVIDER: S-EPMC8263578 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature