Understanding the effect of smoking and drinking behavior on Parkinson's disease risk: a Mendelian randomization study.

ABSTRACT: Previous observational studies have identified correlations between Parkinson's disease (PD) risk and lifestyle factors. However, whether or not those associations are causal remains unclear. To infer causality between PD risk and smoking or alcohol intake, we conducted a two-sample Mendelian randomization study using genome-wide association study summary statistics from the GWAS & Sequencing Consortium of Alcohol and Nicotine use study (1.2 million participants) and the latest meta-analysis from the International Parkinson's Disease Genomics Consortium (37,688 PD cases and 18,618 proxy-cases). We performed sensitivity analyses, including testing for pleiotropy with MR-Egger and MR-PRESSO, and multivariable MR modeling to account for the genetic effects of competing substance use traits on

SUBMITTER: Dominguez-Baleon C 

PROVIDER: S-EPMC8263722 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature