Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation.

ABSTRACT: As a promising future treatment for stroke rehabilitation, researchers have developed direct brain stimulation to manipulate the neural excitability. However, there has been less interest in energy consumption and unexpected side effect caused by electrical stimulation to bring functional recovery for stroke rehabilitation. In this study, we propose an engineering approach with subthreshold electrical stimulation (STES) to bring functional recovery. Here, we show a low level of electrical stimulation boosted causal excitation in connected neurons and strengthened the synaptic weight in a simulation study. We found that STES with motor training enhanced functional recovery after stroke in vivo. STES was shown to induce neural reconstruction, indicated by higher neurite expression in the sti

SUBMITTER: Kim K 

PROVIDER: S-EPMC8263745 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature