The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein.

ABSTRACT: Long-term studies have shown that virus infection affects the energy metabolism of host cells, which mainly affects the function of mitochondria and leads to the hydrolysis of ATP in host cells, but it is not clear how virus infection participates in mitochondrial energy metabolism in host cells. In our study, HUVEC cells were infected with HSV-1, and the differentially expressed genes were obtained by microarray analysis and data analysis. The viral gene encoding protein UL16 was identified to interact with host protein ANT2 by immunoprecipitation and mass spectrometry. We also reported that UL16 transfection promoted oxidative phosphorylation of glucose and significantly increased intracellular ATP content. Furthermore, UL16 was transfected into the HUVEC cell model with mitochondrial dy

SUBMITTER: Li S 

PROVIDER: S-EPMC8263751 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature