Breeding of Ca_v2.3 deficient mice reveals Mendelian inheritance in contrast to complex inheritance in Ca_v3.2 null mutant breeding.

ABSTRACT: High voltage-activated Ca_v2.3 R-type Ca²⁺ channels and low voltage-activated Ca_v3.2 T-type Ca²⁺ channels were reported to be involved in numerous physiological and pathophysiological processes. Many of these findings are based on studies in Ca_v2.3 and Ca_v3.2 deficient mice. Recently, it has been proposed that inbreeding of Ca_v2.3 and Ca_v3.2 deficient mice exhibits significant deviation from Mendelian inheritance and might be an indication for potential prenatal lethality in these lines. In our study, we analyzed 926 offspring from Ca_v3.2 breedings and 1142 offspring from Ca_v2.3 breedings. Our results demonstrate that breeding of Ca_v2.3 deficient mice shows typical Mendel

SUBMITTER: Papazoglou A 

PROVIDER: S-EPMC8263769 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature