Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats.

ABSTRACT: Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting normal development. In the present study we investigated the effects of dietary fat composition on early overnutrition-induced body weight and glucose regulation in Swiss Webster mice, which show susceptibility to high-fat diet-induced diabetes. We compared glucose homeostasis between a high-fat lard-based (HFL) diet, high in saturated fats, and a high-fat olive oil/fish oil-based (HFO) diet, high in monounsaturated and omega-3 fats. We hypothesized that the healthier fat profile of the latter diet would improve early overnutrition-induced glucose dysregulation. However, early over

SUBMITTER: Glavas MM 

PROVIDER: S-EPMC8263808 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature