Identification of an IFN-β-associated gene signature for the prediction of overall survival among glioblastoma patients.

ABSTRACT:

Background

Brain glioblastoma multiforme (GBM) is the most common primary malignant intracranial tumor. The prognosis of this disease is extremely poor. While the introduction of β-interferon (IFN-β) regimen in the treatment of gliomas has significantly improved the outcome of patients; The mechanism by which IFN-β induces increased TMZ sensitivity has not been described. Therefore, the main objective of the study was to elucidate the molecular mechanisms responsible for the beneficial effect of IFNβ in GBM.

Methods

Messenger RNA expression profiles and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) GBM and GSE83300 dataset from the Gene Expression Omnibus. Univariate Cox regression analysis and lasso Cox regression model established a novel 4-g

SUBMITTER: Cheng L 

PROVIDER: S-EPMC8263857 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature