Adaptive immunity-related gene expression profile is correlated with clinical phenotype in patients with acute myeloid leukemia.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a common and lethal hematopoietic malignancy that is highly dependent on the immune microenvironment. However, light has yet to be shed on the landscape of adaptive immunity-related genes. This work aimed to uncover the novel molecular events in AML and potential therapeutic strategies for AML treatment.

Methods

For the current research, the transcriptional information of 732 genes that participate in adaptive immunity was collected from 173 patients with AML, and the patients were grouped into different cohorts based on the different expression patterns. The correlations between gene expression and clinical characteristics, including prognosis, were studied.

Results

According to the notably different expressions of adaptive

SUBMITTER: Chen P 

PROVIDER: S-EPMC8263877 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature