Dataset Information

Hypertermic Intrathoracic Chemotherapy (HITHOC) for thymoma: a narrative review on indications and results.

ABSTRACT:

Objective

With this narrative review, we retraced the history of hypertermic intrathoracic chemotherapy (HITHOC) since the beginning, analyzing literature on operative technique, feasibility and efficacy of this treatment. Moreover, we report the fifteen-year experience of our center in this relatively new technique, for what concerns both early postoperative results and long-term oncological outcomes.

Background

Thymomas are frequently misdiagnosed and recognized in advanced stage, often with pleural dissemination, especially when not associated to Myasthenia Gravis that allows an early diagnosis during the initial assessment. Moreover, the natural history of locally advanced thymoma is characterized by a high rate of pleural or pericardial relapses. Surgery has always been considered a milestone in thymoma's treatment, even in case of serous dissemination or relapses, although his role as exclusive therapy does not guarantee an acceptable local disease control. In case of disseminated disease, different multidisciplinary protocols have been experimented, from chemotherapy to radiation therapy, alone or associated to surgery, in order to increase overall and disease-free survival, but the breakthrough happened in the early 90s with the introduction of HITHOC following surgery. Combination of surgery and HITHOC resulted in less toxic than systemic chemotherapy and providing a good local disease control in patients with stage IVa thymomas or thymoma's pleural recurrences.

Methods

We searched PubMed for relevant literature, up to January 2020, on hypertermic intrapleural chemotherapy for thymomas (TPR or DNT), selecting only those reporting information about HITHOC protocol used, postoperative course and oncological outcomes.

Conclusions

HITHOC is a safe and feasible procedure, with a very low complication rate and negligible systemic effects of chemotherapeutic agents, effective in controlling both TPR and DNT, in particular as regards local disease-free survival.

Keywords

Hypertermic intrathoracic chemotherapy (HITHOC); thymoma; intracavitary chemotherapy; hyperthermia; redo-surgery.

SUBMITTER: Aprile V

PROVIDER: S-EPMC8263885 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Publications

Hypertermic Intrathoracic Chemotherapy (HITHOC) for thymoma: a narrative review on indications and results.

Aprile Vittorio V Bacchin Diana D Korasidis Stylianos S Ricciardi Roberta R Petrini Iacopo I Ambrogi Marcello Carlo MC Lucchi Marco M

Annals of translational medicine 20210601 11

<h4>Objective</h4>With this narrative review, we retraced the history of hypertermic intrathoracic chemotherapy (HITHOC) since the beginning, analyzing literature on operative technique, feasibility and efficacy of this treatment. Moreover, we report the fifteen-year experience of our center in this relatively new technique, for what concerns both early postoperative results and long-term oncological outcomes.<h4>Background</h4>Thymomas are frequently misdiagnosed and recognized in advanced stag ...[more]

PMID: 34350272

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Dataset Information

Hypertermic Intrathoracic Chemotherapy (HITHOC) for thymoma: a narrative review on indications and results.

Objective

Background

Methods

Conclusions

Keywords

Publications

Hypertermic Intrathoracic Chemotherapy (HITHOC) for thymoma: a narrative review on indications and results.

Similar Datasets

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