Hypertermic Intrathoracic Chemotherapy (HITHOC) for thymoma: a narrative review on indications and results.

ABSTRACT:

Objective

With this narrative review, we retraced the history of hypertermic intrathoracic chemotherapy (HITHOC) since the beginning, analyzing literature on operative technique, feasibility and efficacy of this treatment. Moreover, we report the fifteen-year experience of our center in this relatively new technique, for what concerns both early postoperative results and long-term oncological outcomes.

Background

Thymomas are frequently misdiagnosed and recognized in advanced stage, often with pleural dissemination, especially when not associated to Myasthenia Gravis that allows an early diagnosis during the initial assessment. Moreover, the natural history of locally advanced thymoma is characterized by a high rate of pleural or pericardial relapses. Surgery has always been

SUBMITTER: Aprile V 

PROVIDER: S-EPMC8263885 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature