Genetic Variants in COX2 and ALOX Genes and Breast Cancer Risk in White and Black Women.

ABSTRACT: COX and ALOX genes are involved in inflammatory processes and that may be related to breast cancer risk differentially between White and Black women. We evaluated distributions of genetic variants involved in COX2 and ALOX-related pathways and examined their associations with breast cancer risk among 1,275 White and 1,299 Black cases and controls who participated in the Women's Circle of Health Study. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable-adjusted logistic regression models. Our results showed differential associations of certain genetic variants with breast cancer according to menopausal and ER status in either White or Black women. In White women, an increased risk of breast cancer was observed for COX2-

SUBMITTER: Mongiovi JM 

PROVIDER: S-EPMC8263909 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature