Effects of Altering Mitochondrial Antioxidant Capacity on Molecular and Phenotypic Drivers of Fibrocalcific Aortic Valve Stenosis.

ABSTRACT: Background: While a small number of studies suggest that oxidative stress has an influential role in fibrocalcific aortic valve disease (FCAVD), the roles of specific antioxidant enzymes in progression of this disease remain poorly understood. Here, we focused on selectively altering mitochondrial-derived oxidative stress-which has been shown to alter progression of a myriad of age-associated diseases-on the progression of molecular and phenotypic drivers of FCAVD. Methods: We generated low-density lipoprotein receptor-deficient, Apolipoprotein B100-only mice (LA) that were either haploinsufficient for MnSOD (LA-MnSOD ^+/-) or genetically overexpressing MnSOD (LA-MnSOD ^Tg/0). After 6 months of Western diet feeding, mice underwent echo

SUBMITTER: Roos CM 

PROVIDER: S-EPMC8263922 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature