Methylenetetrahydrofolate Reductase Gene C677T Polymorphism-Dietary Pattern Interaction on Hyperhomocysteinemia in a Chinese Population: A Cross-Sectional Study.

ABSTRACT: Background and aim: Hyperhomocysteinemia (Hhcy) has been recognized as a risk factor of several chronic diseases. There is accumulating evidence that both genetic and dietary factors had a notable impact on the risk of Hhcy. The present study aims to investigate the interaction effect on Hhcy between methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and dietary intake. Methods: Data were collected in a cross-sectional survey conducted in China; 3,966 participants with complete information on sociodemographic characteristics, anthropometric measurements, and dietary intake were included in the analyses. Dietary patterns were identified by factor analysis combined with cluster analysis. Blood samples were collected and MTHFR C677T genotypes were

SUBMITTER: Leng S 

PROVIDER: S-EPMC8263928 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature