One carbon metabolism in human lung cancer.

ABSTRACT:

Background

Lung cancer remains the major cause of cancer related death worldwide. The discovery of targeted therapies against activating mutations in genes like EGFR considerably improved the prognosis for a subgroup of patients but still leaves a large part without a targeted therapy. One carbon metabolism (1CM) has been investigated in several cancer entities and its increased activity has been linked to higher tumor aggressiveness and reduced prognosis. In spite of 1CM enzymes role and correlation to cancer cells progression, comprehensive analysis for the diagnostic and functional role of the complete 1CM enzymes in lung cancer has not been conducted so far.

Methods

We investigated the prognostic and functional relevance of five major 1CM factors (MTHFD2, PGDH3, SHMT2, M

SUBMITTER: Yao S 

PROVIDER: S-EPMC8264328 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature