Metabolic and sympathovagal effects of bolus insulin glulisine versus basal insulin glargine therapy in people with type 2 diabetes: A randomized controlled study.

ABSTRACT:

Aims/introduction

This study compares the effects of two different insulin regimens - basal versus bolus insulin - on metabolic and cardiovascular autonomic function in Japanese participants with type 2 diabetes.

Materials and methods

Participants were randomly assigned to groups for therapy with insulin glulisine (IGlu) or insulin glargine (IGla). The primary efficacy end-point was glycemic variability, including M-values, mean of glucose levels, and a blood glucose profile of seven time points before and after the intervention. The secondary end-points included pleiotropic effects, including endothelial and cardiac autonomic nerve functions.

Results

Blood glucose levels at all time points significantly decreased in both groups. Post-lunch, post-dinner, and bedtime b

SUBMITTER: Takeshita Y 

PROVIDER: S-EPMC8264393 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature