Early ART initiation during infancy preserves natural killer cells in young European adolescents living with HIV (CARMA cohort).

ABSTRACT:

Introduction

HIV infection causes pathological changes in the natural killer (NK) cell compartment that can be only partially restored by antiretroviral therapy (ART). We investigated NK cells phenotype and function in children with perinatally acquired HIV (PHIV) and long-term viral control (five years) due to effective ART in a multicentre cross-sectional European study (CARMA, EPIICAL consortium). The impact of age at ART start and viral reservoir was also evaluated.

Methods

Peripheral blood mononuclear cells (PBMCs) from 40 PHIV who started ART within two years of life (early treated patients (ET), ≤6 months; late treated patients (LT), > 6 months), with at least five years of HIV-1 suppression (<40 HIV copies/mL), were collected between November 2017 and August 2018. NK

SUBMITTER: Doria M 

PROVIDER: S-EPMC8264399 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature