Reduction in Hindquarter Vascular Resistance Supports 5-HT₇ Receptor Mediated Hypotension.

ABSTRACT: The 5-HT₇ receptor is the primary mediator of both the acute (chronic (day-week) decreases in mean arterial pressure (MAP) during low dose 5-HT infusion in rats. Previous data show the hypotensive response during chronic 5-HT infusion is due to a decrease total peripheral resistance (TPR) and specifically splanchnic vascular resistance. We hypothesized that changes in vascular resistance in both the splanchnic and skeletal muscle vascular beds are critical to the cardiovascular effects mediated by the 5-HT₇ receptor. Systemic and regional hemodynamic data were collected in conscious and anesthetized male rats using radiotelemetry, vascular catheters and transit-time flowmetry. Reversible antagonism of the 5-HT₇ receptor was achieve

SUBMITTER: Seitz BM 

PROVIDER: S-EPMC8264506 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature